Yes you should choose profile for the second time to run
The difference between Profile and Cookies: Profile saves all information and characteristics of login device such as device type, screen size, video card, etc. Cookies save login state. Using profiles will consume hard drive space. The more you run, the larger the capacity of each profile, but in return increase reliability and reduce accounts lockout. Using cookies takes almost no space, but is not as reliable as using profiles. Cookies will expire within a month, then if you run with cookies, you must delete the cookies folder and let your account log in again. If you run with Profiles, login status is maintained forever.
